Iodixanol Powder

What is Iodixanol?

Iodixanol powder chemical name is Ioxaxol is 6 α- Fluoro-11 β, 21-dihydroxy-16 α- Isopropylidedioxy-1,4-pregnadiene-3,20-dione. The molecular formula is C35H44I6N6O15, and the CAS number is 92339-11-2. It is a White to off-white, amorphous , odorless, hygroscopic powder, soluble in chloroform and ethanol, slightly soluble in dichloromethane and acetone, and insoluble in water.it is used for cone tube angiography, cardiocerebral angiography, and intravenous urography. The principle of its action is to combine iodine to absorb X-rays in blood vessels or tissues, resulting in image display. Iodixanol API has less impact on cardiovascular parameters and femoral blood flow, but it should be taken into account when using it in elderly patients with renal insufficiency undergoing coronary intervention.

The discovery and development of Iodixanol can be traced back to the late 1980s and early 1990s.

In 1987, IBS Pharmaceuticals of the University of Oslo, Norway, began to conduct research on angiography and gradually improved and optimized the molecular structure of known non-ionic X-ray contrast agents, such as the sulfonate compounds of ethylene glycol. In doing so, the researchers discovered a new compound called Iodixanol , which consists of iodine, benzoic acid and cyclohexyl glycolic acid. Compared with other known X-ray contrast agents, the compound has better safety and tolerance, and possesses better imaging quality, so it was quickly widely studied and developed.

In 1996, the European Centre for Liver Research in Norway, in collaboration with IBS, successfully developed a formulation of Iodixanol, which was used in clinical trials for the first time in Europe. In 1999, the drug was approved for marketing by the European Union, making it the world's first commercially available next-generation nonionic X-ray contrast agent. Since then, Iodixanol has been widely used around the world and has gradually become a routine contrast agent for many clinical examinations and interventional surgeries.

 

Basic Information:

Appearance	White to off-white, amorphous , odorless, hygroscopic powder			Structural formula
Molecular Formula	C35H44I6N6O15	Melting point	262-267°C
Formula Weight	1550.18	Boiling point	1250.9±65.0 °C
CAS No.	92339-11-2	Density	1.266 ±0.003
Purity	min 98%	Solubility	Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.

 

Quality standard：

ITEMS	SPECIFICATION
Appearance	White to off-white, amorphous , odorless, hygroscopic powder
Identification	A : IR Spectrum B : HPLC Spectrum
Color of solution	400nm: Not more than 0.200 420nm: Not more than 0.040 450nm: Not more than 0.020
Acidity	Between 5.0-7.0
Clarity of solution	Clear
Water	≤4.0%
Free Iodine	The toluene layer shows no red or pink color
Free Iodide	≤0.001%
Free Aromatic Amine	≤ 0.05%
Limit of Ionic compounds	≤0.02%
Methanol	≤0.005%
Propryleneglycol Monomethyl Ether	≤0.005%
Methoxyethanol	≤0.005%
1,3-dichloro-2-propanol	0.74ppm
        Related Compounds	Iodixanol Related Compound C : NMT 0.33%
	Iodixanol Related Compound D : NMT 0.10%
	Iodixanol Related Compound E : NMT 0.3%
	Iodixanol Related Compound H : NMT 0.6%
	Overalkylated Related Compounds : NMT 1.0%
	Individual unspecified Related(RRT1.23) Compound : NMT 0.10%
	Total Related Compounds : NMT 1.5%
Microbial Limits	Viable cell count test not more than 10 eumycetes cfu/g Not more than 100 bacteria cfu/g Escherichia coli: Not observed
Bacterial endotoxin	Less than 2.0EU/g
Assay	98.6% -101%

 

Only for commercial or research use , not supply for any individual!

 

Fuctions & application 

Iodixanol powder is a contrast agent based on the molecular structure of Iodixanol. It consists of two main components,Iodixanol and iodine, which are obtained by combining the two.

Iodixanol has good biocompatibility and high imaging sensitivity. It is often used in medical imaging for non-invasive diagnosis of various organs and blood vessels of the human body through imaging technology.

it is a widely used contrast agent in medical imaging with high imaging sensitivity and biocompatibility. Attention should be paid to patients' renal function and allergic reaction, as well as reasonable dose control, so as to achieve better imaging diagnosis effect.

 

Important：

Please note that 'this product is a raw material for commercial use only, not personal consumption'. Our company will not be responsible for any risks or consequences caused by personal use.

 

Packing：

1~2kg
2-10kg
10-25kg

 

Shipping：

≤50kg	By express door to door Fedex, DHL,UPS,TNT,EMS ect. Fast and convenient
50kg~200kg	By air Fast and cheap
≥200kg	By sea Cheapest way
Or as your requirement to choose the cheapest way or the fast.

 

Xi'an Yihui Company is a professional enterprise in the production of pharmaceutical raw materials and fine chemicals, including Iodixanol powder. Since its establishment, the company has been committed to providing high-quality products and services, and has now become one of the largest and most powerful manufacturers of Iodixanol API powder in China. The company adheres to the concept of "quality first, service first" and is committed to providing customers with high-quality products and services. It is a trustworthy partner.

 

 

http://www.yihuipharm.com/